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Detector Response

 
 
 
 

Quantitative Chromatographic Analysis
by Raymond P. W. ScottRaymond P. W. Scott,
part of the Chrom-Ed Series

The Detector Response

The detector can contribute unwanted peak deconvolution The detector response index is a means of defining linearity but, it can be used to modify the peak height or peak area calculations and improve quantitative accuracy.

Figure 31. Two Gaussian Curves with Response Indices of 0.95 and 1.05

Two peaks constructed from Gaussian functions using response factors of 0.95 and 1.05 are shown in figure 31. There is a clear difference between the peaks, and the error involved may be considerable. Thus, to obtain a value for the solute concentration, the detector output must be corrected by the response factor. This is a simple calculation and should be included in any data processing software that is not dealing with the ideal detector.

Journal of Chromatographic Science

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