vitamin K

Vitamin K, synthetically derived from 2-methyl-1,4-naphthoquinone and phytol is used to treat blood coagulation disorders. It is most often measured using GC/FID and HPLC.

Vitamin K (phytonadione): CAS No. 84-80-0, C31H46O2, molecular weight 450.69, boiling point 140-145°C (0.001 mmHg), melting point -20°C, density 0.96gm/mL, vapor pressure 0.00mm Hg at 25°C, non flammable, water insoluble is a pale yellow oil or yellow crystals. It is indicated for treatment and prevention of various coagulation disorders involving impaired formation of factors II, VII, IX, and X resulting from Vitamin K deficiency or impairment of Vitamin K activity, including hypoprothrombinemia due to oral anticoagulants, salicylates, and some antibiotics. It does not return abnormal platelet function to normal but is useful in restoring the prothrombin time to normal levels and in decreasing or stopping bleeding episodes. It is synthetically from 2-methyl-1,4-naphthoquinone and phytol. It is most frequently measured in food, plasma and urine using, GC/FID and spectrophotometric methods as well as by reversed phase HPLC.