Figure 52 Determination of Molecular Weight from Low Angle Light Scattering Measurements
The detector sensitivity appears to be similar to that of the refractive index detector and with about the same linearity. However, the greatest advantage of this detector is that it can provide molecular weight data for extremely large molecules.
The Multiple Angle Laser Light Scattering (MALLS) Detector
The multiple
angle laser light scattering detector differs from the low angle device, in that scattering measurements are made at a number
of different angles, none of which are close to the incident light. This
significantly reduces problems associated with light scattering from
particulate contaminants. Data taken at different angles to the incident light
allows the root-mean-square (rms) of the molecular radius 
to
be calculated in addition to the molecular weight of the substance. The
relationship that is used is as follows:
